Association between mycophenolic acid treatment and infection with specific strains of Pneumocystis jirovecii in solid organ transplant recipients in France and Switzerland
Dr. Solène Le Gal & Dr. Gilles Nevez (CHU de Brest) published a study showing P. jirovecii impdh mutations in SOT recipients, suggesting drug-driven selection & transmission.
We are pleased to share that members of our COST Action CA23142, Dr. Solène Le Gal and Dr. Gilles Nevez from CHU de Brest, Laboratoire de Parasitologie-Mycologie, Brest, France, have recently published an important article.
This multicenter study demonstrated that solid organ transplant recipients, particularly those exposed to mycophenolic acid, frequently harbored Pneumocystis jirovecii strains carrying impdh gene mutations (G1020A, G1020T). These mutations, absent in non-SOT controls, suggest drug-driven selection and potential transmission of resistant strains within transplant-associated PCP clusters.
The full article can be accessed through the link available in the Publications section of our website.
Congratulations to our colleagues for this valuable contribution to the field!
