Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(99)03320-6/abstract
This study evaluated whether point mutations in the Pneumocystis carinii DHPS gene, a key enzyme in folate biosynthesis, are linked to prior sulpha drug exposure. The findings assess their potential impact on treatment efficacy and clinical outcomes in HIV-1 patients with PCP.
Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in HIV-1-infected individuals. Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis. We assessed whether mutations in the DHPS gene of P. carinii were associated with exposure to sulpha drugs and influenced outcome from PCP.
